Author information Copyright and License information Disclaimer. Role of ultrasonography in the diagnosis and management of thyroid cancer. The mean size of the nodule was The outcome of a study conducted in, shows that the immunohistochemical expression of Galectin-3 can serve as a highly specific marker of malignancy. The aim of this study was to estimate the sensitivity and specificity of FNAC in detecting malignancy for thyroid disease using histopathology as the gold standard.
Sinna EA, Ezzat N. O Box Gulu – Uganda. Characteristics of the patients presented with clinically solitary thyroid nodule. Innocent Mutyaba for helping with the statistical analysis. The categorization of the smears after cytological diagnosis was done in accordance with The Bethesda System for reporting thyroid cytopathology. According to this study the sensitivity of Galectin-3was found to be
This was a cross sectional study with both prospective and retrospective arms carried fnca from January to April For the retrospective arm, enough information was extracted as much as possible from the cytology and histopathology reports. The difference could probably be attributed to the fact that a significant proportion thyfoid long standing multinodular goiter in areas endemic for iodine deficiency tend to undergo malignant transformation Duration of symptoms in weeks, Median IQR.
Clinical and histopathological patterns. In term of imaging, ultrasonography, as a main modality in the management of patients with thyroid nodules, has some very useful discriminatory values in distinguishing benign from malignant lesion 47 Results A total of 75 patients with solitary thyroid nodule were identified: The total number of thyroid nodules was 32; 15 nodules were in cnac right lobe; 13 nodules in the left lobe and 4 nodules in the isthmus.
Discovery and characterization of an epithelial-specific galectin in the endometrium that forms crystals in the trophectoderm. Nevertheless its sensitivity in differentiating malignant from benign thyroid neoplasms is somewhat less.
Journal of Thyroid Research
Waiver of consent was obtained for the retrospective arm of the study. The paraffin wax embedded tisssue specimens were sliced into very thin sections of 3—10 microns thick. Il Giornale di chirurgia.
Interviews were conducted with all fully consenting patients using a standard pretested questionnaire aimed at capturing patients’ history, examination and investigation findings. Comparison of FNAC with histopathological findings was performed.
Fine needle aspiration cytology is a simple, easy to perform, cost effective, and easily repeated procedure for the diagnosis of thyroid cancer. Most goiters in resource poor settings are multinodular and this emphasizes the fact that iodine deficiency still remains top most cause of thyroid disorders on the African continent 13 — In the FNAC technique, equipment involved glass slides, cover slips, antiseptics, disposable gloves, fixative absolute ethyl alcohol ,swabs, 23 French Fr gauge hypodermic needles 23Fr, 24Fr, 25 Fr is recommended and 10 ml syringes.
It is often used as the initial screening test for diagnosis of thyroid nodules [ 1 ]. Fast scout scan in sagittal, axial and coronal planes was obtained.
Nevertheless no noteworthy association between size and duration of growth and the presence of malignancy was found. Despite several studies showing a high accuracy with FNAC, emerging studies especially in tropical Africa and other developing countries with a high prevalence of nodular thyroid disease, have shown the accuracy of FNAC to be lower than previously reported 4 — 5 and its diagnostic performance has been shown to vary across different studies 6.
This was a prospective study conducted on 75 consecutive patients between January and December Comparison of FNAC with histopathological findings was performed.
The Accuracy of Manual Fine Needle Aspiration Cytology in the Evaluation of Thyroid Cancer
Discussion The aim of this study was to estimate the sensitivity and specificity of FNAC in detecting malignancy thygoid thyroid disease using histopathology as the gold standard. The present study was undertaken to correlate the FNAC findings with histopathology so that rate of unnecessary thyoidectomies in benign pathologies should be avoided.
Photomicrograph showing negative control for Galectin-3staining in thyroid follicular cells on FNAC X, Photomicrograph showing Positive control for Galectin-3staining in Anaplastic large cell lymphoma X, Photomicrograph showing strong positive Galectin-3staining in thyroid follicular cells on FNAC and Photomicrograph showing weak positive Galectin-3staining in thyroid follicular cells thesks FNAC.
None of the tumor revealed the histology of anaplastic or medullary carcinoma. The Mulago hospital endocrine surgical outpatient clinic attends to about 25—30 patients with thyroid disease every week and an annual increase of about — new patients with thyroid disease has been reported over the last five years Mulago hospital records.
The median age of patients was 42 years, the youngest was 16 years and the oldest was 78 years.
On Ultrasound scan, majority of patients Results A total of 75 patients with solitary thyroid nodule were identified: Knowledge on the burden of thyroid disease in Uganda is still limited.
Fischer S, Asa SL. Majority of these nodules are benign.